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Previous Speakers

Brain Disorder Conferences, Neurodegenerative Disorders, Pediatric Neurology, Best Psychiatriy conferences, Neurology Congress, Mental Health Disorders, Neurological Disorder, Pediatric Neurologist, Neurosurgeon, Neuro-ophthalmologist, Top Neuroscience Conferences, Neurology Conference - 2025, index, conference index, event listings, program index

Francesca Bertossi

Giuliano Isontina University Health Authority Italy

Brain Disorder Conferences, Neurodegenerative Disorders, Pediatric Neurology, Best Psychiatriy conferences, Neurology Congress, Mental Health Disorders, Neurological Disorder, Pediatric Neurologist, Neurosurgeon, Neuro-ophthalmologist, Top Neuroscience Conferences, Neurology Conference - 2025, index, conference index, event listings, program index

Dusan Kuljancic

University of Novi Sad Serbia

Brain Disorder Conferences, Neurodegenerative Disorders, Pediatric Neurology, Best Psychiatriy conferences, Neurology Congress, Mental Health Disorders, Neurological Disorder, Pediatric Neurologist, Neurosurgeon, Neuro-ophthalmologist, Top Neuroscience Conferences, Neurology Conference - 2025, index, conference index, event listings, program index

Sandra Moehr

REHAB Basel Switzerland

Brain Disorder Conferences, Neurodegenerative Disorders, Pediatric Neurology, Best Psychiatriy conferences, Neurology Congress, Mental Health Disorders, Neurological Disorder, Pediatric Neurologist, Neurosurgeon, Neuro-ophthalmologist, Top Neuroscience Conferences, Neurology Conference - 2025, index, conference index, event listings, program index

Eldad Katorza

Sheba Medial Center Israel

Brain Disorder Conferences, Neurodegenerative Disorders, Pediatric Neurology, Best Psychiatriy conferences, Neurology Congress, Mental Health Disorders, Neurological Disorder, Pediatric Neurologist, Neurosurgeon, Neuro-ophthalmologist, Top Neuroscience Conferences, Neurology Conference - 2025, index, conference index, event listings, program index

Berta L Brusilovsky

Polytechnic University of Madrid Spain

Brain Disorder Conferences, Neurodegenerative Disorders, Pediatric Neurology, Best Psychiatriy conferences, Neurology Congress, Mental Health Disorders, Neurological Disorder, Pediatric Neurologist, Neurosurgeon, Neuro-ophthalmologist, Top Neuroscience Conferences, Neurology Conference - 2025, index, conference index, event listings, program index

Sajitha S

Cochin University of Science and Technology India

Brain Disorder Conferences, Neurodegenerative Disorders, Pediatric Neurology, Best Psychiatriy conferences, Neurology Congress, Mental Health Disorders, Neurological Disorder, Pediatric Neurologist, Neurosurgeon, Neuro-ophthalmologist, Top Neuroscience Conferences, Neurology Conference - 2025, index, conference index, event listings, program index

Maria Garcia

Polytechnic University of Catalonia Spain

Brain Disorder Conferences, Neurodegenerative Disorders, Pediatric Neurology, Best Psychiatriy conferences, Neurology Congress, Mental Health Disorders, Neurological Disorder, Pediatric Neurologist, Neurosurgeon, Neuro-ophthalmologist, Top Neuroscience Conferences, Neurology Conference - 2025, index, conference index, event listings, program index

Faheem Ahmad Reegu

Jazan University Saudi Arabia

BRAIN DISORDER - 2025

About Conference


We are excited to announce the upcoming "6th Global Summit on Brain Disorders and Therapeutics," set to take place in the vibrant city of Madrid, Spain, on  April 23-24, 2025. This prestigious event will highlight cutting-edge advancements and breakthroughs in neurology and neuroscience under the theme "Exploring Novel Therapies and Advancements in Brain Disorders"

BRAIN DISORDER - 2025 promises to be a landmark gathering, uniting global experts dedicated to advancing neurological research, improving patient care, and enhancing the quality of life for those affected by neurological disorders. Attendees will have the opportunity to engage in insightful presentations, share their latest research, and explore innovative solutions to some of the most pressing neurological challenges of our time. The conference will feature a diverse range of sessions, workshops, and networking opportunities, tailored to meet the interests and objectives of both seasoned professionals and emerging researchers. Join us in Madrid, or participate online, as we embark on an inspiring journey of discovery, innovation, and collaboration in the field of neurology and neuroscience.

Sessions & Tracks

Track 01: Neurodegenerative Disorders

Neurodegenerative disorders are conditions where the nervous system progressively deteriorates, leading to the loss of nerve cells (neurons) and affecting movement, cognition, and other functions. Common examples include Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). These disorders are chronic, worsen over time, and currently have no cure, with treatments mainly focused on managing symptoms and slowing progression.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 02: Mental Health Disorders

Mental health disorders are a range of conditions that affect a person's mood, thinking, behavior, and overall well-being. Common mental health disorders include depression, anxiety, bipolar disorder, and schizophrenia. These conditions can lead to significant distress and impair daily functioning. Mental health disorders are treatable, often through a combination of therapy, medication, and lifestyle changes. Early intervention and ongoing support are key to managing symptoms and improving quality of life.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 03: Neurodevelopmental Disorders

Neurodevelopmental disorders typically manifest early in childhood and can lead to impairments in personal, social, academic, or occupational functioning. Common neurodevelopmental disorders include Autism Spectrum Disorder (ASD), Attention-Deficit/Hyperactivity Disorder (ADHD), Intellectual Disability, and specific learning disorders like dyslexia. Neurodevelopmental disorders are a group of conditions that affect the development and functioning of the brain and nervous system.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 04: Neurological Infections

Neurological infections are diseases caused by bacteria, viruses, fungi, or parasites that affect the brain, spinal cord, or nerves. These infections, such as meningitis and encephalitis, can lead to serious symptoms like fever, headaches, seizures, and neurological damage. Prompt diagnosis and treatment are crucial to prevent long-term complications or death.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 05: Stroke and Cerebrovascular Disorders

Stroke and cerebrovascular disorders involve disruptions in blood flow to the brain, leading to brain damage. A stroke occurs when a blood vessel in the brain is blocked or bursts, causing symptoms like sudden weakness, speech difficulties, and vision problems. Other cerebrovascular disorders include transient ischemic attacks (mini-strokes) and aneurysms. These conditions are medical emergencies requiring immediate treatment to minimize brain damage and improve recovery outcomes.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 06: Brain Tumors and Neuro-Oncology

Brain tumors are abnormal growths in the brain that can be benign or malignant. Neuro-oncology is the field of medicine that specializes in diagnosing and treating these tumors. Symptoms of brain tumors may include headaches, seizures, and neurological deficits, depending on the tumor's location and size. Treatment often involves a combination of surgery, radiation, and chemotherapy, with the goal of removing or controlling the tumor while preserving brain function. Early detection and specialized care are crucial for improving outcomes.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 07: Epilepsy and Seizure Disorders

Epilepsy is a neurological condition characterized by recurrent, unprovoked seizures due to abnormal electrical activity in the brain. Seizure disorders vary in type and severity, from brief lapses in attention to full-body convulsions. Management typically involves medication to control seizures, and in some cases, surgery or lifestyle changes. Early diagnosis and effective treatment are key to improving quality of life for those affected.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 08: Brain Injury and Traumatic Brain Injury

Brain injury refers to damage to the brain caused by trauma, such as a fall or accident, or by internal factors like stroke or disease. It can result in cognitive, physical, and emotional impairments. The severity of the injury affects the extent of recovery and rehabilitation needs. Traumatic Brain Injury (TBI) occurs when an external force, such as a blow or jolt to the head, causes damage to the brain. Symptoms can range from mild, such as brief loss of consciousness, to severe, including extended unconsciousness and memory loss. TBI can lead to long-term cognitive, physical, and emotional impairments.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 09: Alzheimer’s and Parkinson’s Diseases

Alzheimer’s disease is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes. Parkinson’s disease involves the gradual loss of dopamine-producing neurons, leading to motor symptoms such as tremors, rigidity, and bradykinesia. Both conditions currently have no cure, but treatments aim to manage symptoms and improve quality of life.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 10: Sleep Disorders

Sleep disorders are conditions that disrupt normal sleep patterns, affecting overall health and quality of life. Common types include insomnia, sleep apnea, restless legs syndrome, and narcolepsy. These disorders can lead to daytime fatigue, difficulty concentrating, and increased risk of other health issues. Diagnosis typically involves sleep studies, and treatment may include lifestyle changes, medication, or specialized therapies to improve sleep quality and restore normal rest patterns.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 11: Neuroimmunology and Neuroinflammation

Neuroimmunology studies the interactions between the nervous system and the immune system, while neuroinflammation refers to inflammation within the brain and spinal cord. Neuroinflammation can result from various conditions, including infections, autoimmune diseases, and neurodegenerative disorders, potentially leading to neuronal damage and cognitive decline. Understanding these processes is crucial for developing treatments for diseases like multiple sclerosis and Alzheimer's disease.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 12: Neuropharmacology and Therapeutic Innovations

Neuropharmacology explores how drugs affect the nervous system, aiming to develop therapies for neurological and psychiatric conditions. Therapeutic innovations in this field focus on creating new medications and treatment approaches to improve symptoms and outcomes for disorders such as depression, epilepsy, and neurodegenerative diseases. Advances often involve targeted drug development and personalized medicine to enhance efficacy and minimize side effects.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 13: Advanced Neuroimaging and Diagnostic Tools

Advanced neuroimaging and diagnostic tools use cutting-edge technology to visualize and analyze the brain and nervous system. Techniques like MRI, PET, and fMRI provide detailed images and functional information, aiding in the diagnosis and monitoring of neurological disorders. These tools enhance understanding, improve diagnostic accuracy, and guide treatment planning for conditions such as tumors, strokes, and neurodegenerative diseases.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 14: Neuromodulation and Brain Stimulation Therapies

Neuromodulation and brain stimulation therapies involve using electrical or magnetic techniques to alter brain activity and treat neurological and psychiatric disorders. Methods like transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS) can improve symptoms of conditions such as depression, Parkinson's disease, and chronic pain. These therapies aim to modulate brain function and enhance treatment outcomes through targeted stimulation.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 15: Novel Treatment Strategies

Novel treatment strategies involve innovative approaches to managing diseases, often through new drugs, therapies, or technologies. In neurology and neuroscience, this includes targeted therapies, gene editing, and advanced neurostimulation techniques aimed at improving outcomes for conditions like Alzheimer's, Parkinson's, and brain injuries. These strategies seek to enhance efficacy and minimize side effects compared to traditional treatments.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 16: Neuroinformatics and Computational Neuroscience

Neuroinformatics and computational neuroscience use data analysis and modeling to understand brain function and structure. Neuroinformatics involves managing and analyzing brain data, while computational neuroscience employs mathematical models and simulations to explore neural processes. Together, they advance knowledge of brain mechanisms and improve diagnostic and therapeutic approaches.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 17: Ethical and Legal Issues in Neurology

Ethical and legal issues in neurology involve considerations like patient consent, autonomy, and confidentiality, particularly in cases of diminished capacity or neurodegenerative diseases. Issues also include the use of experimental treatments and the allocation of resources. Addressing these concerns ensures that patients' rights are protected and that care is provided in a fair and just manner.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 18: Patient Care and Rehabilitation

Patient care and rehabilitation in neurology focus on restoring function and improving quality of life for individuals with neurological conditions. This involves personalized treatment plans, including physical, occupational, and speech therapy, to address specific impairments and promote recovery. Comprehensive care also includes support for emotional well-being and daily living activities.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Track 19: Case Studies and Clinical Trials

In neurology and neuroscience, case studies offer detailed observations of individual patients with neurological disorders, providing insights into disease progression and treatment effects. Clinical trials test new therapies or interventions on larger groups to assess their safety and effectiveness in treating conditions like epilepsy, stroke, or neurodegenerative diseases. Both approaches are crucial for advancing understanding and improving patient care.

Related Conferences: BRAIN DISORDER - 2025 | Stroke Meeting 2025 | Euro Dementia 2025 | Neurophysiology 2025

Related Worldwide Associations and Societies: American Neurological Association | World Federation of Neurology | European Federation of Neurological Associations | Functional Neurological Disorder Society

Market Analysis

The global neurology market was valued at USD 3.34 billion in 2023 and is projected to grow from USD 3.60 billion in 2024 to USD 7.08 billion by 2033, with a compound annual growth rate (CAGR) of 7.60% during the forecast period of 2024 to 2033. A key factor driving this growth is the aging population in emerging countries, which is leading to a higher incidence of neurological disorders.

Neurology is the branch of medicine focused on diagnosing and treating diseases that affect the nervous system, including the brain, spinal cord, and nerves. This field addresses a wide range of conditions, from common issues like neuropathies and headaches to more severe diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis. Neurological diseases significantly impact patients' quality of life, often leading to sensory, motor, and cognitive impairments. The market's growth is propelled by increasing awareness of neurological conditions, expanding therapeutic options, rising healthcare spending, and advancements in genetic and neuroimaging research. Additionally, efforts to boost research funding and improve healthcare standards are expected to further support the expansion of the neurology market.

Neurology Market Trends

  • Ongoing innovation in diagnostic tools and treatments, driven by continuous research in neuroscience, is expected to fuel market growth.
  • Increased collaboration among neurosurgeons, neurologists, and other specialists is anticipated to drive further advancements in the field.
  • Growing awareness of neurological health is leading to earlier interventions and diagnoses, which is also estimated to contribute to market growth.

Benifits of Participation

Benefits for Speaker

  • Gain global recognition for your research profile worldwide.
  • Earn professional credits to support your career advancement.
  • Stay updated with the latest advancements in cutting-edge research.
  • Foster lasting connections through social and networking events.
  • Promote your research effectively through a one-page ad featured in abstract books and flyers, reaching a million views and significantly enhancing your research profile.
  • Expand your knowledge beyond your core field of Brain Disorders and Therapeutics by exploring new subjects and areas of study.
  • Experience a unique blend of networking, learning, and enjoyable interactions, all in one comprehensive package.

Benefits for Delegate

  • Enhance your professional development by deepening your understanding and knowledge.
  • Your involvement contributes to the development of innovative methodologies and ideologies that can expand business and industry outcomes.
  • Connect with fellow Brain Disorders and Therapeutics summit researchers and experts, fostering opportunities to exchange fresh ideas and insights within the field.

Benefit for Sponsor

  • Immerse yourself in an international environment to enhance the potential for new company opportunities.
  • Showcase your company's latest technologies, new products, or services to a diverse global audience.
  • Boost your business growth by generating leads through active participation.
  • Building a successful company requires considerable time, effort, and determination. It's invaluable to have a network of colleagues and associates who share a common drive and objective to draw inspiration from.
  • Evaluate and advance your organizational strategies by benchmarking against leading industry plans.
  • Gain valuable insights and solutions to your company's questions and challenges through feedback from trusted experts during our webinars.
  • Elevate your company's branding and marketing through prominent placement of your company's logo on our banners, website, and other event materials.

Benefit for Collaborators

  • This is the premier platform globally for showcasing Brain Disorders and Therapeutics to an extensive audience.
  • Cultivate enduring professional relationships.
  • Elevate your subscriber/member base by 40% through strategic placement of your organization's branding, marketing materials, promotional content, and logo on our banners, website, and event materials.
  • Listing your company in the Global Business forum will significantly amplify its exposure through our event.
  • Your representatives can engage in valuable networking opportunities to enhance their knowledge and understanding of your organization's services and offerings alongside key delegates.
  • Brain Disorders and Therapeutics advertising materials, including posters, brochures, pamphlets, and services, will be seamlessly integrated with information and distributed to hospitals, universities, societies, and researchers.

who should attend?

·  Neurologists and Neuroscientists

·  Psychiatrists and Psychologists

·  Neurosurgeons

·  Medical Researchers and Academicians

·  Pharmaceutical and Biotech Professionals

·  Healthcare Providers and Clinicians

·  Medical Students and Trainees

·  Policy Makers and Health Administrators

·  Patient Advocacy Groups

·  Technology Developers and Innovators

Past Conference Report

Brain Disorder 2024

Conference Series takes a great pride in announcing the “5th Global Summit on Brain Disorders and Therapeutics” (Brain Disorder 2024) which was held during February 08-09, 2024 at NH LAS TABLAS in Madrid, Spain. Brain Disorder 2024 witnessed an amalgamation of peerless speakers who enlightened the crowd with their knowledge and confabulated on various new-fangled topics related to the field of neuroscience and neurology. The extremely illustrious conference hosted by Conference Series was marked with the attendance of young and brilliant researchers, business delegates and talented student communities representing more than 25 countries around the world. Brain Disorder 2024, The conference aimed a parallel rail with theme “Enlightening the New Horizons in Brain Disorders and Neuro science”. The meeting engrossed a vicinity of cognizant discussions on novel subjects like Brain Injury and Rehabilitation, Neuro-oncology & Brain Tumors, Brain Cancer & Tumors, Mental Disorder / Mental illness / Psychiatric Disorders, Neuroinformatics and Computational Neuroscience and other allied areas of neuroscience and neurology. The conceptual and applicable knowledge shared, will also foster organizational collaborations to nurture scientific accelerations.

The Organizing Committee would like to thank the moderator, for his contribution which resulted in smooth functioning of the conference. Brain Disorder 2024, The conference was embarked with an opening ceremony followed by a series of lectures delivered by both Honourable Guests and members of the Keynote forum. The highlights of the conference were the keynote forum by Sandra Gunhild Erika Moehr, Switzerland, gave their fruitful contributions in the form of highly informative presentations and made the conference a top notch one, Conference Series - 5th Global Summit on Brain Disorders and Therapeutics Meet would not have reached the pinnacle if not with the support of International, multi-professional steering committee and coordination of the International Journal of Mental Health & Psychiatry, and journal of Neuroscience & Clinical Research; hence, we express our deep sense of gratitude, After the successful completion of Brain Disorder 2024, we are glad to announce our next upcoming conference “5th Global Summit on Brain Disorders and Therapeutics” (BRAIN DISORDER- 2024) which is going to be held on August 05-06, 2024 inParis, France. with the theme "Rebuilding Minds: Neurorehabilitation and Therapeutic Breakthroughs .

To Collaborate Scientific Professionals around the World

Conference Date April 23-24, 2025

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Brain Disorders & Therapy Research & Reviews: Neuroscience Journal of Translational Neurosciences International Journal of Mental Health & Psychiatry

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Keytopics

  • Alzheimer's Disease
  • Amyotrophic Lateral Sclerosis (ALS)
  • Anxiety Disorders
  • Attention Deficit Hyperactivity Disorder (ADHD)
  • Autism Spectrum Disorder
  • Bipolar Disorder
  • Blood-brain Barrier
  • Brain-computer Interface
  • Cognitive Impairment
  • Cognitive-behavioral Therapy
  • Deep Brain Stimulation
  • Dementia
  • Depression
  • Epilepsy
  • Huntington's Disease
  • Migraine
  • Multiple Sclerosis
  • Neurodegenerative Disorders
  • Neurogenesis
  • Neuroimaging
  • Neuroinflammation
  • Neuropharmacology
  • Neuroplasticity
  • Neurotransmitters
  • Parkinson's Disease
  • Psychopharmacology
  • Schizophrenia
  • Stroke
  • Synaptic Plasticity
  • Traumatic Brain Injury