Excitotoxic Cell Damage

Excitotoxic cell damage is a pathological process in which nerve cells (neurons) are damaged or killed as a result of excessive and prolonged stimulation by excitatory neurotransmitters, such as glutamate. While these neurotransmitters are crucial for normal brain function and communication between neurons, an overabundance can lead to harmful effects. Excitotoxicity can occur in various neurological conditions, including strokes, traumatic brain injuries, and neurodegenerative diseases like Alzheimer's and Parkinson's. It involves the excessive activation of receptors on neurons, leading to an influx of calcium ions and other harmful processes that ultimately result in cell death. Researchers and clinicians are continually studying excitotoxicity to develop strategies and medications that can mitigate its damaging effects, potentially offering new avenues for the treatment of neurological disorders.

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